Dementia

Volume 5, Issue 3, November declination 2010; Article-005 ISSN 0976 044X Research Article minocycline IMPROVES MEMORY IN MORRIS water system MAZE TASK IN INTRACEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS Vivek Kumar Sharma1* and Ashok Kumar Goyal2 * Govt. College of Pharmacy, Rohru, Dist. Shimla-171207, Himachal Pradesh,India 2 Onkar College of Pharmacy, Sunam, Dist. Sangrur, Punjab, India *Corresponding authors E-mail: viveksharma_pharma@yahoo.co.in 1 go done on: 21-10-2010; Finalized on: 14-12-2010. compendium In the register study, the upshot of minocycline was studied against intracerebroventricular streptozotocin mother spatial store deficit. man-sized wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with minocycline (10, 20 and 40 mg/kg, ip) for 17 days start from day 1 of streptozotocin hold in separate groups. The spatial storehouse was evaluated using the Morris sozzled maze task. The intracerebroventricular streptozotocin inf apply rats showed significant memory deficits and minocycline showed significant do drugs dependent improvement in the task.

The study demonstrated the strength of minocycline in preventing spatial memory deficit bring on by streptozotocin and its potential in age related neurodegenerative dis track down lodges where memory impairment is convolute such as Alzheimers infirmity. Keywords: Minocycline, spatial memory, ICV streptozotocin rats, Morris water maze. ingress Alzheimers disease (AD) is a advancing neurodegenerative disorder with a mean duration of just about 8.5 old age among onset of clinical symptoms and death1. AD is the most vernacular bring of dementia in the elder population. The most widely used sermon for Alzheimers disease at present argon acetylcholinesterase inhibitors, which aim to prolong blueprint cognitive process through increased synaptic activity, without providing neuroprotection. This treatment is only characteristic and provides pocketable outcomes...If you want to get a full essay, order it on our website: Orderessay

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