Invitro Olive

International Journal of Pharmaceutics 166 (1998) 123 133 In vitro evaluation of the antioxidant instinctive action and bio membrane interaction of the plant phenols oleuropein and hydroxytyrosol Antonella Saija a,*, Domenico Trombetta a, Antonio Tomaino a, Rossella Lo Cascio a, Pietro Princi b, Nicola Uccella c, Francesco Bonina d, Francesco Castelli e a department Farmaco-Biologico, School of Pharmacy, Uni6ersity of Messina, 98168 Messina, Italy b C.I.I.F.T., Uni6ersity of Messina, 98168 Messina, Italy c CIRASAIA, Uni6ersity of Calabria, Calabria, Italy d Department of pharmaceutical Sciences, Uni6ersity of Catania, Catania, Italy e Department of chemical Sciences, Uni6ersity of Catania, Catania, Italy Received 4 princely 1997; received in revise form 18 airy latitude 1997; accepted 18 December 1997 Abstract Oleuropein and hydroxytyrosol, ii phenolic compounds contained in olives and olive oil, argon known to take in several biological properties, many of wh ich may be related, partially at least, to their antioxidant and free mathematical group-scavenger ability.

Hence, together with their scavenging action against the persistent 1,1-diphenyl-2-picrylhydrazyl radical (DPPH test), we have investigated the antioxidative prepare of oleuropein and hydroxytyrosol in a mock up system consisting of dipalmitoylphosphatidylcholine/linoleic acid unilamellar vesicles (DPPC/LA LUVs) and a water-soluble azo compound as a free radical beginning (LPLUV test). The results obtained were also interpreted in the light of biophenol interactions, examine by differential scanning calorimetry (DSC), with dimyristoylphosphatidylcholine (DMPC) vesicles as a bi ological membrane model. Our results obtaine! d in the DPPH and LP LUV tests con?rm the good scavenger occupation and antioxidant effect of oleuropein and hydroxytyrosol. However, while both compounds exhibit comparable intensity in the DPPH test (hydroxytyrosol being slightly more alert than oleuropein), oleuropein seems, in the LPLUV test, a...If you want to get a full essay, enjoin it on our website: OrderEssay.net

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